Table 4.

Interventions and Outcomes of VLBW Infants (<1500 g BW; n = 3779 ; Range Among Centers in Parentheses)

Birth Weight Category (Grams)Total
<750750 to 9991000 to 12491250 to 1499
Number of Infants744 (4–112)874 (6–103)1051 (10–139)1110 (12–121)3779
Survival (%)62 (0–83)86 (72–100)95 (72–100)96 (91–100)87
Respiratory morbidity*
 CLD (%)54 (0–100)33 (7–59)20 (8–60)10 (0–33)26
 Postnatal steroid (% received)44 (0–91)39 (12–62)20 (0–44)7 (0–50)25
 Median days on oxygen28 (0–105)16 (0–39)5 (0–42)1 (0–23)5
 Median days on ventilation42 (3–65)25 (0–36)7 (1–16)2 (0–22)7
Retinopathy of prematurity
 Eye examination54 (20–75)70 (19–82)59 (27–96)33 (15–92)53
 None (%)30 (0–100)47 (16–78)71 (33–100)81 (46–100)5
 States 1–2 (%)41 (0–63)41 (22–75)26 (0–50)19 (0–55)33
 ≥Stage 3 (%)29 (0–86)12 (0–29)3 (0–17)1 (0–6)11
 Laser/cryotherapy (% treated)9 (0–38)4 (0–18)1 (0–7)03
Intraventricular hemorrhage
 Cranial U/S examination74 (12–100)88 (15–100)87 (32–100)78 (35–100)82
 None (%)54 (30–100)63 (39–100)73 (44–96)78 (49–100)68
 Grades 1–2 (%)27 (0–50)25 (0–44)21 (5–44)18 (0–42)22
 ≥Grade 3 (%)19 (0–46)12 (0–35)7 (0–19)4 (0–15)10
 Ventriculo-peritoneal shunt (%)1 (0–10)2 (1–12)1 (1–15)1 (0–22)1
Patent ductus arteriosus (%)
 Indomethacin treatment only (%)30 (2–100)30 (4–60)19 (6–50)11 (0–32)21
 Surgically ligated only (%)7 (0–49)3 (0–19)1 (0–6)1 (0–4)2
 Combination (indocid/surgical) (%)10 (0–23)8 (0–24)3 (0–9)1 (0–17)5
Nosocomial infection (%)29 (3–70)29 (0–72)21 (4–78)13 (3–67)22
NEC
 Medical (%)6 (0–19)6 (0–20)3 (0–22)3 (0–8)4
 Surgical (%)5 (0–11)3 (0–12)2 (0–11)1 (0–4)3
Survival without major morbidity(%)37 (0–71)56 (39–80)75 (38–92)86 (58–100)69
  • * CLD was defined as oxygen dependency at 36 weeks' CGA for infants born at ≤32 weeks' GA (n = 3494). Complete data were available for 3000 infants.

  • Major morbidity defined as presence of CLD, NEC, ≥grade 3 IVH, or ≥grade 3 ROP. Complete data were available for 3118 infants.