Table 3.

Overdoses* Compared With Number of Administrations*

DrugTotal AdministrationsTotal OverdosesDeath or Permanent Neurologic Injury Associated With OverdoseRange of Overdoses as a Fraction of Maximal Recommended Dose
Opioids371071.3–4
Benzodiazepines33431.5–4.62
Sedative/hypnotics451181.25–3.0
Barbiturates20761.32–6.0
Ketamine8411.54–4.14
Local anesthetics14332.06–3.5
Totals1573928
  • * Some patients received >1 drug in an overdose.6,7,94

  • Overdose was defined as ≥1.25 the maximal recommended dose.