Table 6.

Side Effects Observed During 50:50 Nitrous Oxide Oxygen Mixture Inhalations in 1019 Children



Whole
Sample§
n = 1019
Inhalation LengthPsychotropic Drug
Association
<10 Minutes
n = 696
>10 Minutes
n = 323
Yes
n = 135
No
n = 884
%%%%%
None62.863.860.760.975
Euphoria20.120.619.012.121.4
Change in visual or auditory perception7.06.58.08.76.7
Dream5.75.56.1.76.5
Nausea and vomiting3.73.34.61.42.4
Deep sedation2.12.51.22.91.9
Paresthesia1.71.91.201.9
Dizziness1.61.32.1.71.7
Restlessness1.51.41.52.11.4
Nightmare and hallucination1.21.01.5.71.3
Miscellaneous* 1.91.03.710.710
  • * Headache (n = 6), shivering (n= 3), cough (n = 2), hypotonia (n = 2), limb pain (n = 1), erection (n = 1), hypersalivation (n = 1), fixed gaze (n= 1), hiccup (n = 1), and pallor (n = 1).

  • Comparisons of inhalation length <10 minutes versus >10 minutes were not statistically significant in all groups but miscellaneous (P < .01).

  • Comparisons of groups yes versus no were statistically significant only for euphoria (P = .01) and dream (P < .01).

  • § Some patients had <1 side effect; thus, total of percentages is higher than 100%.