Table 4.

Clinical and Biological Characteristics Associated With AIDS Occurrence in 54 HIV-infected Children, the Mother-to-Child Transmission Study Cohort, Kigali, Rwanda, 1988–1994

Number
Children
Number
With AIDS
UnivariateMultivariate Analysis
PHR (95% CI)P
Estimated age at HIV infection
 ≤3 mo359.58
 >3 mo195
First HIV-related signs or symptoms
 Failure to thrive2810.074.7 (1.4–16.1).01
 Lymphadenopathy2412.00115.0 (3.1–73.9).001
 Oral candidiasis112.89
 Generalised dermatitis86<.0011.0 (0.2–4.7).97
 Severe pneumonia73.30
 Chronic diarrhea51.40
 Chronic cough42.59
 Chronic fever21.08
 Hepatomegaly11<.001
 Splenomegaly11<.001
Interval between HIV infection and
 first HIV-related signs or
 symptoms
 ≤6 mo308.131.0 (0.2–5.5).94
 >6 mo246
HIV-related signs/symptoms
 preceding AIDS occurrence
 Failure to thrive4211.62
 Chronic cough398.090.3 (0.1–1.3).11
 Lymphadenopathy3510.28
 Hepatomegaly246.44
 Splenomegaly194.44
 Generalised dermatitis175.79
 Severe pneumonia154.34
 Chronic diarrhea151.01
 Lymphoid interstitial pneumonitis141.010.04 (0.01–0.4).005
 Oral candidiasis132.53
 Chronic fever72.89
 Chronic parotitis50.11
Maternal CD4 count at d 15
 <35051.87
 ≥3503911
Child CD4/CD8 ratio at 6 mo
 <1215.91
 ≥1217