Table 1.

Frequency of Clinical Signs of Brain Injury Among Subjects With ICI and Odds Ratios for ICI in Subjects With and Without These Signs

Clinical SignFrequency in Those
With ICI (%)
(n = 30)
Odds Ratio Among Those
Subjects Who Had Head
CT (n = 188) (With 95% CI)
Odds Ratio Among All
Subjects (n = 608)
(With 95% CI)
Historical features
 Loss of consciousness1 (3)0.33 (0.04, 2.57)1.2 (0.16, 9.45)
 Lethargy8 (27)3.17 (1.26, 8.02)* 9.19 (3.77, 22.55)*
 Irritability9 (30)1.08 (0.46, 2.52)2.41 (1.11, 5.23)*
 Seizures2 (7)1.33 (0.27, 6.60)4.48 (0.92, 21.74)
 Vomiting2 (7)0.63 (0.14, 2.89)1.52 (0.34, 6.71)
Physical examination findings
 Depressed mental status
  Any8 (27)1.42 (0.59, 3.42)4.90 (2.10, 11.48)*
  Moderate or worse6 (20)2.37 (0.86, 6.53)9.38 (3.46, 25.64)*
  Severe2 (7)11.15 (0.98, 127.07)40.43 (9.19, 177.8)*
 Irritability8 (27)1.00 (0.42, 2.39)2.71 (1.18, 6.24)*
 Focal neurologic findings1 (3)
 Bulging fontanel4 (13)24.0 (2.58, 223.26)* 22.1 (5.71, 85.52)*
 Vital signs indicating increased ICP2 (7)5.5 (0.94, 32.7)20.57 (3.50, 121.33)*
One or more of the above
 features (symptomatic)
16 (52)0.92 (0.42, 1.99)2.96 (1.43, 6.12)*