TABLE 3

Common Bleeding Symptoms of Healthy Individuals and Patients With VWD

SymptomsHealthy Individuals (n = 500; n = 341; n = 88; n = 60), %All Types of VWD (n = 264; n = 1885),%Type 1 VWD (n = 42; n = 671), %Type 2 VWD (n = 497), %Type 3 VWD (n = 66; n = 385), %
Epistaxis4.6–22.738.1–62.553–616366–77
Menorrhagia23.0–68.447–60323256–69
Bleeding after dental extraction4.8–41.928.6–51.517–313953–70
Ecchymoses11.8–50.049.2–50.450NRNR
Bleeding from minor cuts and abrasions0.2–33.336364050
Gingival bleeding7.4–47.126.1–34.829–313556
Postoperative bleeding1.4–28.219.5–2820–472341
Hemarthrosis0–14.96.3–8.32–3437–45
Gastrointestinal tract bleeding0.6–27.7145820
  • NR, not reported. Reprinted with permission from Nichols WL, Hultin MB, James AH, et al. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel Reports (USA). Haemophilia. 2008;14(2):186.