Table 1.

Initial Clinical and Laboratory Findings in Patients With Meningococcal Disease From the Meningococcal Database*

CharacteristicUMD
(n = 45)
Overt
Meningococcal
Disease§
(n = 336)
P
Demographics
 Age in months21 (± 40) 49 (± 57) <.001
  Age 3–36 months37/45 (82%) 177/336 (53%) <.001
Vital signs
 Temperature (°C)39.9 (± .8)39.0 (± 1.2)<.001
CBC
 WBC (× 109/L)14.0  (± 5.6)15.0  (± 9.7).36 
  WBC ≥15 × 109/L14/41 (34%) 145/335 (43%) .32 
  WBC <5 × 109/L 1/41 (2%)  50/335 (15%) .03 
 % Bands16  (± 13)21  (± 13).04 
 ABC (× 109/L)2.3  (± 2.1)3.4  (± 3.7)<.01 
 ANC (× 109/L)9.1  (± 4.9)11.7  (± 9.3)<.01 
 Platelets (× 109/L)390  (± 142)258  (± 138)<.001
  • Abbreviations: UMD, unsuspected meningococcal disease; CBC, complete blood count; WBC, white blood cell count; ABC, absolute band count; ANC, absolute neutrophil count.

  • * Values reported are those from the visit at which the positive culture was obtained. For UMD patients, this was at an outpatient visit, and for patients with overt disease, this was on the day of admission.

  • Continuous variables reported as means (± standard deviation).

  • Of patients with UMD, WBC recorded in 41, ANC recorded in 38, band count recorded in 35 and platelets recorded in 30.

  • § Of patients with overt meningococcal disease, WBC recorded in 335, ANC recorded in 329, band count recorded in 300, and platelets recorded in 319.