Table 3.

Shifts in ACTH Stimulation Test From Baseline to Double-blind Treatment Phase (Week 12)*

BaselineAdrenal Function at End of Double-blind Treatment
ACTH Stimulation
Test
Placebo
n = 27
0.25 mg QD
n = 30
0.25 mg BID
n = 27
0.5 mg BID
n = 28
1.0 mg QD
n = 22
AbnNormAbnNormAbnNormAbnNormAbnNorm
Abn2141112
Norm322425320323217
  • Abbreviations: Abn, abnormal; Norm, normal.

  • * Total n for each treatment group was based on patients with nonmissing ACTH and basal cortisol data on baseline and week 12.

  • Normal (“norm”) adrenal function was defined as basal plasma coritsol >150 nmol/L and either ACTH-stimulated plasma cortisol increased by 200 nmol/L above basal cortisol level or ACTH-stimulated plasma cortisol >400 nmol/L after 60 minutes.