Table 3.

Adverse Effects

InfantsControl
(n = 10)
Minimal
(n = 6)
Mild
(n = 6)
Seizures: 452
Minimum glucose, mM4.2  ± 1.82.0  ± 1.22.9  ± 0.8
Glucose, <2.6 mM 241
Minimum pH (during cooling)7.32  ± 0.27.34  ± 0.067.34  ± 0.06
Minimum base excess, mM−5  ± 8−9  ± 6−4  ± 2
pH <7.30 (cooling) 001
Hypotension (MAP <40) 000
Bradycardia (<80 bpm) 000
Cardiac arrhythmia 000
Persistent pulmonary hypertension of the newborn (nitric oxide) 220
Meconium aspiration 230
Infection 100
Minimum platelets (× 109/L)182  ± 50142  ± 46202  ± 84
Thrombocytopenia (<150 × 109) 221
Acute renal failure1066
Maximum creatinine
 mM0.17  ± 0.80.21  ± 0.120.13  ± 0.05
 mg/dL1.92  ± 0.172.37  ± 1.361.47  ± 0.57
Minimum sodium, mM134  ± 4131  ± 2135  ± 1
Hyponatremia (<135 mM) 663
Minimum potassium, mM3.8  ± 1.03.2  ± 0.74.1  ± 0.9
Hypokalemia (<3.5 mM) 542
  • Abbreviations: MAP, mean arterial pressure; bpm, beats per minute.