Table 2.

Pharmacokinetic Parameters of Ritonavir Suspension at Steady State (Day 28 of Monotherapy; Median and Range) in Children >2 Years of Age (n = 37)

Dose Level
(mg/m2/dose)
nAge (years)Weight (kg)Tmax (h)Cmax(μg/mL)AUC6–12 (μg · h/mL)t1/2 (h)Cl/F (L/m2/h)
25087.7  (3.8–13.6)20.8  (13.5–29.6)3.0  (1.0–6.0)9.3  (3.9–19.0)45.9  (20.9–111.3)2.2  (1.8–3.4)5.3  (2.2–11.8)
300912.1  (2.4–13.9)33.1  (15.0–52.4)3.0  (2.0–4.0)9.8  (5.5–17.1)49.2  (27.2–97.2)2.7  (2.1–3.7)6.0  (3.0–11.1)
350108.8  (2.7–13.9)21.0  (8.1–77.2)2.0  (1.0–4.0)12.7  (5.3–19.6)59.9  (19.7–95.6)2.6  (2.0–3.3)6.1  (3.6–17.8)
400104.8  (2.3–14.4)16.3  (10.3–50.0)1.5  (1.0–4.0)11.4  (3.6–32.8)97.0  (21.4–219.3)4.0  (2.5–9.2)4.3  (1.9–19.2)
  • T max indicates time to maximum concentration; C max, maximum concentration; AUC, area under the time concentration curve; t 1/2, half-life; Cl/F, apparent clearance.