Table 4.

DTaP and DTP Vaccine Efficacy Against Laboratory Confirmed B pertussis Infection* After 3 and 4 Doses of Vaccine

Clinical Case Definition
Mild and Typical
Pertussis
Efficacy (95% CI)
Typical Pertussis
Efficacy (95% CI)
DTaPDTPDTaPDTP
After 3 doses62%78%78%93%
(38 –77)(62 –88)(60 –88)(83 –97)
After 4 doses76%85%85%93%
(66 –83)(78 –90)(77 –91)(88 –96)
  • * Isolation of B pertussis by culture or significant ELISA antibody rise to PT or a household contact to a B pertussis culture confirmed case.

  • Cough illness of ≥7 days' duration.

  • Modified WHO clinical definition requiring 21 days of cough with either paroxysmal cough, whoop or posttussive vomiting.