Table 1.

New Therapies for Hypoxic–Ischemic Encephalopathy

Hypothermia, brain only
MgSO4
Oxygen-free radical inhibitors, allopurinol
Calcium channel blockers
Inhibitors of nitric oxide production
Monoganglioside GM
NMDA receptor antagonists (MK801)
Nerve growth factor (IGF)
CO2 control
SNO S-nitrosohemoglobin
Combination of above
  • According to the Pharmaceutical Research and Manufacturers of America (1997), there are 146 new medicines in development for children. Only 8 of these are for neurologic diseases of children, all for epilepsy.

    No therapies for hypoxic–ischemic encephalopathy in children are being developed.