Table 2.

Comparison of Clinical Data Between CF Patients Carrying the G85E Mutations and Patients Homozygous or Compound Heterozygous for Two Severe Mutations (W1282X and ΔF508) and Those Carry a Milder Mutation (3849+10kb C−>T)

VariableG85EW1282X/W1282X ΔF508/ΔF508 W1282X/ΔF5083849 + 10kb C−>T
n12 40 21
Age at diagnosis*3.7 ± 6.30.7 ± 1.8 13.2 ± 7.8
Sweat chloride (mmol/L)*119 ± 38111 ± 1271 ± 18
Died, n 4 2 2
Pancreatic sufficiency, %§25 079
Meconium ileus, %§ 033 0
Current age, y12.8 ± 8.510.8 ± 7.019.8 ± 8.8
Weight (percentile)28 ± 3424 ± 2450 ± 34
Forced expiratory volume in 1 second  (% predicted)55 ± 26  (n = 7)66 ± 28  (n = 24)55 ± 21  (n = 19)
  • * P < .0001,

  • P < .001,

  • P < .01 analysis of variance for three means.

  • § P < .002 χ2 test of three populations.

  • P < .0001 F test of equal variance compared with G85E.

  • P < .01 F test of equal variance compared with G85E.