Table 7.

Incidence of Death, BPD, and Survival Without Chronic Lung Disease at 28 Days After Birth and at 36 Weeks Postconceptional Age

ExosurfInfasurfRisk Ratio*
(Infasurf/Exosurf)
95% Confidence Interval
n/N(%)n/N(%)
At 28 days after birth
 Death66 /423(16)50 /423(12)0.750.54, 1.04
 BPD,60 /349(17)63 /354(18)1.010.73, 1.39
 Survival,§
  On room air106 /423(27)112 /420(27)1.110.86, 1.28
  Fio2 < 0.3252 /423(60)248 /420(59)1.010.91, 1.12
  Without BPD289 /415(70)291 /404(72)1.040.96, 1.13
At 36 Weeks postconceptional age
 Death73 /423(17)64 /423(15)0.870.65, 1.16
 BPD,41 /335(12)50 /339(15)1.290.88, 1.90
 Survival,#
  On room air211 /423(50)205 /419(49)1.000.88, 1.13
  Fio2 < 0.3321 /423(76)321 /419(77)1.000.93, 1.08
  Without BPD294 /408(72)289 /403(72)0.990.92, 1.08
  • * Adjusted for center and birth weight.

  • On supplemental oxygen with Toce-Edwards score ≥4 on 21 to 35 day chest radiograph. Per number of evaluable survivors.

  • Oxygen requirement unknown for 3 Infasurf-treated infants.

  • § Chest radiograph not available for 8 Exosurf-treated and 19 Infasurf-treated infants.

  • On supplemental oxygen with Toce-Edwards score ≥4 on 34 to 38 week check radiograph. Per number of evaluable survivors.

  • Oxygen requirement unknown for four Infasurf-treated infants.

  • # Chest radiograph not available for 15 Exosurf-treated and 20 Infasurf-treated infants.