Table 3.

Risk of HUS by Medications Begun Within 3 Days of Diarrheal Illness Onset

FactorProportion of Patients With Factor Who Developed HUSProportion of Patients Without Factor Who Developed HUSRate Ratio (95% CI)P Value
Number/Total (%)Number/Total (%)
Any antimicrobial agent8/50 (16)28/218 (13)1.3 (0.6–2.6).56
TMP/SMZ*6/31 (19)30/234 (13)1.5 (0.7–3.3).32
Antimotility agent8/34 (24)28/238 (12)2.0 (1.0–4.0).10
Adsorbent and/or antimotility agent8/43 (19)28/229 (12)1.5 (0.7–3.1).26
  • * Trimethoprim/sulfamethoxazole.

  • Includes dicyclomine, diphenoxylate, Donnatal, hyoscyamine sulfate, loperamide, or narcotic.

  • Attapulgite, kaolin-pectin.