TABLE 1

Clinical and Laboratory Findings in Children With TMP-SMX ADRs at Our Institution

ED (N = 69)Hospitalized (N = 40)P
Age, y, mean8.369.41
Boy, n (%)21 (30)19 (48).08
Clinical signs, n (%)
 Rash66 (96)37 (93).49
 Mucous membrane involvement5 (7)19 (48)<.01
 Documented fever4 (6)23 (58)<.01
 Mental status changes0 (0)2 (5).13
 Vomiting4 (6)12 (30)<.01
 Diarrhea0 (0)6 (15)<.01
Laboratory findings, n (%)
 White blood cell count <4.54/7 (57)11/38 (29).20
 Hemoglobin level <10.50/7 (0)10/38 (26).32
 Platelet count <1501/7 (14)11/38 (29).66
 Alanine aminotransferase >1000/5 (0)9/31 (29).30