TABLE 18

Studies of Antiinflammatory Medications for the Treatment of OSAS

MedicationSourceLevelNo.Duration, wkRandomizedPlacebo-ControlledBaseline AHI (per h)AHI on Treatment (per h)P
Intranasal steroidsBrouillette et al152II13 OSAS6YesYes10.7 ± 9.45.8 ± 7.9.04
12 controls
Intranasal steroidsAlexopoulos et al154III27 OSAS4NoNo5.2 ± 2.23.2 ± 1.5<.001
Intranasal steroidsKheirandish-Gozal and Gozal153I62 OSAS6; crossoverYesYes3.7 ± 0.31.3 ± 0.2<.001
MontelukastGoldbart et al82IV24 OSAS16NoNo3.0 ± 0.22.0 ± 0.3.017
16 controls
Intranasal steroids + montelukastKheirandish et al155IV22 OSAS12NoNo3.9 ± 1.20.3 ± 0.3<.001
14 controls