TABLE 3

Multivariable Model for the Association Between Antianaerobic Antibiotic Exposure and IBD Developmenta

VariableNDeveloped IBDUnadjusted HR (95% CI)aHR (95% CI)
Antianaerobic antibioticsb
 Exposed618 6634366.00 (1.93–18.66)5.51 (1.66–18.28)
 Unexposed453 7633121 (Reference)
Family history of IBD
 Present3561242.05 (23.77–74.39)35.57 (19.67–64.31)
 Absent1 072 0707361 (Reference)
Gender
 Female516 9043050.76 (0.66–0.88)0.75 (0.64–0.87)
 Male555 5224431 (Reference)
Chronic granulomatous disease
 Present194286.62 (107.29–765.74)243.93 (76.89–773.78)
 Absent1 072 4077441 (Reference)
Primary sclerosing cholangitis
 Present179734.29 (380.36–1417.57)852.12 (328.43–2210.88)
 Absent1 072 4097391 (Reference)
Socioeconomic deprivationc
 Most deprived866 909760.76 (0.60–0.96)0.75 (0.57–0.97)
 All others140 7696451 (Reference)
  • a Excludes exposures during the median latency period (3.9 months) before cohort censorship for all subjects.

  • b Represents the increased hazard of developing IBD with exposure before 1 year of age; hazard decreased with increasing age.

  • c Subject numbers do not sum to overall cohort totals due to missing values.