TABLE 4

Effect of Timing of Exposure on the Association With JIA

ExposuresAny AntibioticAny Untreated Infection
Timing of ExposureNExposedAdjusted OR (95% CI)aPExposedAdjusted OR (95% CI)aP
Before JIA diagnosis1672
 Unexposed (reference)JIA 1521927
Control 1520373315
 >24 mo241.0 (0.5–1.9).91340.7 (0.4–1.3).25
  392469
 12–24 mo251.7 (0.9–3.2).11321.1 (0.6–1.9).85
  243284
 6–12 mo302.9 (1.6–5.3).001170.7 (0.4–1.5).37
  187194
 0–6 mo543.1 (1.7–5.5)<.001421.4 (0.8–2.4).24
325258
Before JIA diagnosis or antecedent joint symptom or rheumatology referral1672
 Unexposed (reference)JIA 1522431
  Control 1520404328
 >24 mo221.0 (0.5–1.9).90330.7 (0.4–1.3).31
  328411
 12–24 mo231.4 (0.8–2.6).27270.8 (0.5–1.5).52
  250281
 6–12 mo231.7 (0.9–3.1).10170.7 (0.4–1.4).31
216211
 0–6 mo603.0 (1.8–4.9)<.001441.2 (0.7–2.0).43
322289
  • a Models adjusted for matching and any personal autoimmune disease.