TABLE 3

Association of Antibiotic Prescription Dose With JIA

VariableNExposedUnadjusted ORAdjusted ORa95% CIP
No. of antibiotic courses1672
 Unexposed (reference)JIA 15219
Control 1520373
 1–2 courses411.71.50.8–2.7.16
497
 3–5 courses462.92.51.4–4.4.002
342
 >5 courses463.53.01.6–5.6<.001
308
Each additional antibiotic courseb1.101.091.05–1.13<.001
No. of antibiotic weeks1672
 Unexposed (reference)JIA 15220
Control 1520392
 1–2 wk401.71.50.9–2.7.14
470
 3–5 wk432.82.41.3–4.3.003
324
 >5 wk493.32.91.6–5.2<.001
334
Each additional week of antibioticsb1.071.061.03–1.10<.001
Secondary case definitions (no. of antibiotic courses)
 JIA + drug for JIA1221
  Unexposed (reference)JIA 11114
     Control 1110267
  1–2 courses311.71.50.8–3.0.23
     360
  3–5 courses332.72.31.2–4.6.02
     251
  >5 courses333.22.71.3–5.5.007
   232
 JIA + rheumatology referral1100
  Unexposed (reference)JIA 10010
    Control 1000237
  1–2 courses241.91.60.7–3.5.22
     324
  3–5 courses273.32.71.2–5.9.01
     224
  >5 courses395.64.62.1–10.0<.001
215
 JIA + management ≥3 mo1298
  Unexposed (reference)JIA 11814
  Control 1180280
  1–2 courses321.71.50.8–2.9.24
  396
  3–5 courses342.82.41.2–4.7.01
  262
  >5 courses383.83.11.6–6.4.001
242
 JIA + any secondary definition1474
  Unexposed (reference)JIA 13415
  Control 1340316
  1–2 courses381.91.60.9–3.1.12
  443
  3–5 courses382.92.41.2–4.6.009
  305
  >5 courses434.03.31.7–6.4.001
276
  • a Models adjusted for matching, any infection, and any personal autoimmune disease.

  • b Numbers of total courses and weeks of antibiotics were truncated at the upper 2.5 percentile (18 courses and 25 weeks, respectively) to limit the influence of outliers.