Trisomy 21 Effect on Odds of ROP Incidence in a VLBW (BW <1500 g) Cohort and in an Extremely Low BW (BW <750 g) Subcohort

Trisomy 21 Effect on Odds of ROP Incidence, OR (95% CI)
Univariate Logistic RegressionMultivariate Logistic Regression
VLBW cohort (N = 99 080)
 With ROP (of any stage)0.4 (0.3–0.5)0.6 (0.5–0.8)
 With advanced ROP (stages 3–5)0.3 (0.1–0.6)0.4 (0.1–0.9)
Extremely low BW subcohort (N = 16 549)
 With ROP (of any stage)0.3 (0.1–0.6)0.3 (0.1–0.5)
 With advanced ROP (stages 3–5)0.4 (0.1–1.2)0.3 (0.1–1.1)
  • Multivariate logistic regression adjusted for GA, BW, CHDs, patent ductus arteriosus, Apgar scores, and oxygen exposure (Fio2 [fraction of inspired oxygen] and number of days receiving ventilation, high-flow nasal cannula, and continuous positive airway pressure). CI, confidence interval; OR, odds ratio.