TABLE 2

Comparison of ROP and Other Comorbidities of Neonates With Trisomy 21 to Neonates Without Trisomy 21 in a VLBW Cohort (BW <1500 g)

Trisomy 21 (N = 321)Non–Trisomy 21 (N = 98 759)P2 or t Test)
ROP, % (n)
 ROP (any stage)19.3 (62)37.8 (36 915)<.001
 Advanced ROP (stages 3–5)2.2 (7)6.5 (6429)<.001
 Treated for ROP (cryo, laser, surgery)1.3 (4)3.6 (3593)<.01
Other disorders, % (n)
 CHDs (ASD, VSD, pulmonary stenosis, tetrology of Fallot)37.4 (120)9.8 (9700) <.001
 PDA48.9 (157)40.5 (40 026)<.001
 Brain hemorrhage (any type)0.9 (3)0.3 (320)Nonsignificant
 Necrotizing enterocolitis6.8 (22)7.0 (6649)Nonsignificant
 Bronchopulmonary dysplasia29.6 (95)25.5 (25 222)Nonsignificant
 Sepsis11.5 (37)14.0 (13 833)Nonsignificant
  • ASD, atrial septal defect, cryo: cryotherapy VSD: ventricular septal defect; cryo, cryotherapy; PDA, patent ductus arteriosus; VSD, ventricular septal defect.