TABLE 5

Regional Clusters of Gray Matter Demonstrating Steeper Negative or Positive Correlations (Peak Intensity) Between Decreased OWLS Listening Score and Regional Volume in Exposed Children Compared With Matched, Previously Unexposed Children

Gray Matter VolumePredominant RegionsTotal No. of VoxelsPeak MNI Coordinates (x, y, z), mmPeak Intensity
DecreasedCluster 15825.5, –55.5, 0−3.79
Right cerebrum58
Right lingual gyrus52
Occipital lobe36
Lingual gyrus28
Gray matter17
Parahippocampal gyrus15
Limbic lobe15
Subgyral13
Brodmann area 3011
DecreasedCluster 21539, –69, 18−3.32
Right cerebrum15
Temporal lobe15
Middle temporal gyrus15
Right middle temporal10
  • Voxel (volumetric pixel) is a 3-dimensional element, with an approximate volume of 2 mm3. Coordinates denote 3-dimensional location (left to right, posterior to anterior, and inferior to superior) of voxel cluster according to a standardized system based on the Montreal Neurological Institute (MNI) classification; peak intensity represents the maximum nuclear magnetic resonance signal intensity in a voxel cluster.