TABLE 4

Regional Clusters of Gray Matter Demonstrating Steeper Negative or Positive Correlations (Peak Intensity) Between Decreased Performance IQ and Regional Volume in Exposed Children Compared With Matched, Previously Unexposed Children

Gray Matter VolumePredominant RegionsTotal No. of VoxelsPeak MNI Coordinates (x, y, z), mmPeak Intensity
DecreasedCluster 1406−10.5, -49.5, -7.5−3.95
Culmen237
Cerebellum, anterior lobe237
Left cerebellum233
Left lingual gyrus232
Left cerebrum164
Occipital lobe161
Left cerebellum157
Lingual gyrus145
Gray matter56
Brodmann area 1937
Brodmann area 1818
Vermis17
DecreasedCluster 26316.5, –52.5, –3−3.77
Right lingual gyrus57
Right cerebrum56
Lingual gyrus51
Occipital lobe51
Gray matter25
Brodmann area 1915
DecreasedCluster 354−40.5, 19.5, –10.5−3.76
Frontal lobe54
Inferior frontal gyrus54
Left cerebrum54
Left inferior frontal gyrus, orbital part52
IncreasedCluster 12854, –13.5, 13.53.44
Right cerebrum28
Right rolandic operculum28
Gray matter20
Brodmann area 4319
Postcentral gyrus13
Parietal lobe13
Precentral gyrus12
Frontal lobe12
  • Voxel (volumetric pixel) is a 3-dimensional element, with an approximate volume of 2 mm3. Coordinates denote 3-dimensional location (left to right, posterior to anterior, and inferior to superior) of voxel cluster according to a standardized system based on the Montreal Neurological Institute (MNI) classification; peak intensity represents the maximum nuclear magnetic resonance signal intensity in a voxel cluster.