TABLE 3

Classification of Neurodevelopmental Outcomes at 18–22 mo and 6–7 y Among Survivors of HIE

All Participants
Classification of MDI at 18–22 mo, nTotal Population, n Classification of IQ at 6–7 ySurvivors Free of CP at 6–7 y, n Classification of IQ at 6–7 ySurvivors With CP at 6–7 y, n Classification of IQ at 6–7 y
>84[70, 84]<70Total, n (%)>84[70, 84]<70Total, n (%)>84[70, 84]<70Total, n (%)
All Participants
 >843912253 (48)3812252 (60)1a001 (4)
 70–841213227 (25)1213227 (31)0000 (0)
 <70122730 (27)1247 (8)0022b,c22 (96)
 Total, n (%)52 (47)27 (25)31 (28)110b (100)51 (59)27 (31)8 (9)86 (100)1 (4)0 (0)22b (96)23 (100)
 Change from MDI at 18–22 mo to IQ at 6–7 yCategorical (>84, [70, 84], <70)Numeric ValuesMean Numeric Change (SD)
  Unchanged7930
  Deteriorated1664−10.2 (7.2)
  Improved154312.0 (8.9)
Hypothermia Participants
 >84229233 (52)229233 (62)0000 (0)
 70–8487217 (27)87217 (32)0000 (0)
 <70011213 (21)0123 (6)009b9 (100)
 Total, n (%)30 (48)17 (27)16 (25)63b (100)30 (57)17 (32)6d (11)53 (100)0 (0)0 (0)9b (100)9 (100)
Normothermia Participants
 >84173020 (43)163019 (58)1a001 (7)
 70–8446010 (21)46010 (30)0000 (0)
 <70111517 (36)1124 (12)001313 (93)
 Total, n (%)22 (47)10 (21)15 (32)47 (100)21 (64)10 (30)2 (6)33 (100)1 (7)0 (0)13 (93)14 (100)
  • Percentages do not necessarily add up to 100% because of rounding.

  • a Child with hemiplegia.

  • b One child treated with hypothermia is missing CP status at 6–7 y. The child had CP at the 18-mo follow-up visit and was categorized as having the primary outcome based on severe developmental delay, blindness, and epilepsy.

  • c Among children with IQ <70 with CP (N = 22), cranial MRI lesions included 16 with basal ganglia, thalamic, internal capsule, and cerebral lesions (NRN score 2B), 1 with basal ganglia, thalamic, and internal capsule lesions only (NRN score 2A), and 1 with hemispheric devastation (NRN score 3); 4 did not have an MRI.38

  • d Of the 6 children treated with hypothermia who had IQ <70 but no CP, 4 had cranial MRI before NICU discharge. Two had normal scans, 1 had cerebral lesions only (NRN score 1B), and 1 had basal ganglia, thalamic, internal capsule, and cerebral lesions (NRN score 2B).