TABLE 2

Cognitive Assessments at 18–22 mo and 6–7 y

All ParticipantsHypothermiaNormothermiaHypothermia vs Normothermia
P
18- to 22-mo neurodevelopmental assessment
 MDIN = 110N = 63N = 47
  Mean (SD)79.7 (20.1)81.9 (19.2)76.8 (21.0).19
  Median (Q1, Q3)83 (68, 94)85 (72, 93)79 (50, 94)
  (Minimum, maximum)(49, 128)(49, 128)(49, 113)
  >84, n (%)53 (48)33 (52)20 (43).31
  70–84, n (%)27 (25)17 (27)10 (21)
  55–69, n (%)6 (5)2 (3)4 (9)
  <55, n (%)24 (22)11 (17)13 (28)
6- to 7-y neurodevelopmental assessment
 Full Scale IQaN = 110N = 63N = 47
  Mean (SD)78.5 (23.8)80.9 (23.3)75.3 (24.4).23
  Median (Q1, Q3)83 (65, 96)83 (69, 98)81 (40, 91)
  (Minimum, maximum)(39, 121)(39, 121)(39, 116)
  >84, n (%)52 (47)30 (48)22 (47).75
  70–84, n (%)27 (25)17 (27)10 (21)
  55–69, n (%)8 (7)5 (8)3 (6)
  <55, n (%)23 (21)11 (17)12 (26)
 Verbal IQN = 91N = 55N = 36
  Mean (SD)86.1 (17.1)85.9 (19.1)86.4 (13.7).88
  Median (Q1, Q3)85 (75, 101)85 (72, 102)85.5 (77, 96)
  (Minimum, maximum)(46, 118)(46, 118)(46, 112)
  >84, n (%)51 (56)30 (55)21 (58).10
  70–84, n (%)25 (27)12 (22)13 (36)
  55–69, n (%)10 (11)9 (16)1 (3)
  <55, n (%)5 (5)4 (7)1 (3)
 Performance IQN = 91N = 55N = 36
  Mean (SD)91.0 (16.8)91.3 (17.3)90.5 (16.3).82
  Median (Q1, Q3)90 (82, 101)93 (81, 104)89 (84, 100.5)
  (Minimum, maximum)(45, 127)(45, 127)(45, 127)
  >84, n (%)59 (65)35 (64)24 (67).76
  70–84, n (%)24 (26)16 (29)8 (22)
  55–69, n (%)5 (5)2 (4)3 (8)
  <55, n (%)3 (3)2 (4)1 (3)
 Processing speed quotientN = 87N = 53N = 34
  Mean (SD)92.9 (17.0)93.2 (17.2)92.4 (17.0).84
  Median (Q1, Q3)94 (83, 103)94 (83, 104)91 (80, 102)
  (Minimum, maximum)(45, 143)(45, 123)(49, 143)
  >84, n (%)62 (71)39 (74)23 (68).61
  70–84, n (%)21 (24)11 (21)10 (29)
  55–69, n (%)0 (0)0 (0)0 (0)
  <55, n (%)4 (5)3 (6)1 (3)
 Attention or executive function core domain scoreN = 77N = 46N = 31
  Mean (SD)93.7 (16.6)94.5 (15.1)92.6 (18.7).63
  Median (Q1, Q3)95 (85, 104)95 (85, 104)95 (82, 110)
  (Minimum, maximum)(50, 121)(52, 121)(50, 119)
  >84, n (%)60 (78)38 (83)22 (71).19
  70–84, n (%)11 (14)6 (13)5 (16)
  55–69, n (%)3 (4)0 (0)3 (10)
  <55, n (%)3 (4)2 (4)1 (3)
  No score, n (%)33/110 (30)17/63 (27)16/47 (34)
   Untestable29 (26)14 (22)15 (32)
    Due to neurologic or cognitive impairment24 (22)11 (17)13 (28)
    Other reasons5 (5)3 (5)2 (4)
   Missing, no reason4 (4)3 (5)1 (2)
 Visuospatial core domain scoreN = 84N = 50N = 34
  Mean (SD)97.7 (16.2)98.5 (15.6)96.5 (17.2).58
  Median (Q1, Q3)97 (85, 109)97 (88, 109)97 (85, 112)
  (Minimum, maximum)(57, 132)(57, 132)(57, 127)
  >84, n (%)70 (83)42 (84)28 (82).89
  70–84, n (%)11 (13)6 (12)5 (15)
  55–69, n (%)3 (4)2 (4)1 (3)
  <55, n (%)0 (0)0 (0)0 (0)
  No score, n (%)26/110 (24)13/63 (21)13/47 (28)
   Untestable23 (21)11 (17)12 (26)
    Due to neurologic impairment20 (18)8 (13)12 (26)
  Due to cognitive impairment3 (3)3 (5)0 (0)
    Due to other reasons3 (3)2 (3)1 (2)
   Missing, no reason
  • At 18 mo, the BSID-II MDI was used to assess neurodevelopmental outcomes. At 6–7 y, the WPPSI-III (n = 93) or Wechsler Intelligence Scale for Children, Fourth Edition Full Scale IQ (n = 17) and the Neuropsychological Assessment (NEPSY) attention or executive function (n = 77) and visuospatial processing subscales (n = 84) were used to assess cognitive outcomes. Test score comparisons were conducted with Fisher exact tests for categorical data and 2-sided t tests for continuous data. Q1, quartile 1; Q3, quartile 3.

  • a Children deemed so severely impaired as to preclude psychometric evaluation (n = 19) were assigned a Full Scale IQ of 39. No scores were imputed for verbal IQ, performance IQ, or processing speed quotient.