TABLE 3

Unadjusted and Adjusted Changes in BASC-2 Scores at 3 Years of Age With 10-Fold Increases in Creatinine-Standardized Gestational and Childhood Urinary BPA Concentrations

Change in BASC-2 Score, Estimate (95% CI)
All, UnadjustedAll, AdjustedGirls, AdjustedaBoys, Adjusteda
Mean gestational BPA level (n = 239)
    Aggression scale1.6 (−3.4 to 6.6)2.1 (−2.7 to 6.9)5.0 (−2.1 to 12)−0.2 (−6.8 to 6.4)
    Hyperactivity scale−0.6 (−5.0 to 3.8)0.5 (−3.8 to 4.8)9.1 (3.1 to 15)−6.3 (−12 to −0.6)b
    Anxiety scale6.8 (1.6 to 12)7.0 (1.7 to 12)12 (4.7 to 20)1.3 (−5.8 to 8.4)b
    Depression scale2.7 (−2.3 to 7.7)4.9 (0.0 to 9.9)11 (3.6 to 18)−0.5 (−7.2 to 6.2)b
    Somatization scale0.4 (−3.7 to 4.6)0.3 (−3.9 to 4.5)5.0 (−1.1 to 11)−4.0 (−9.6 to 1.7)b
    Attention scale−2.2 (−6.0 to 1.6)−1.7 (−5.5 to 2.1)−0.5 (−6.0 to 5.1)−2.2 (−7.4 to 3.0)
Mean childhood BPA level (n = 225)
    Aggression scale2.7 (−1.3 to 6.6)1.6 (−2.4 to 5.7)0.7 (−4.8 to 6.2)3.1 (−2.8 to 9.1)
    Hyperactivity scale0.3 (−3.0 to 3.7)−1.0 (−4.4 to 2.4)−1.2 (−5.8 to 3.3)0.5 (−4.4 to 5.4)
    Anxiety scale2.7 (−1.6 to 6.9)2.9 (−1.5 to 7.4)1.3 (−4.7 to 7.4)3.3 (−3.1 to 9.8)
    Depression scale4.3 (0.4 to 8.2)3.0 (−1.1 to 7.1)2.8 (−2.8 to 8.4)2.9 (−3.1 to 8.9)
    Somatization scale3.3 (0.0 to 6.6)1.6 (−1.8 to 5.1)2.0 (−2.7 to 6.8)1.1 (−4.0 to 6.2)
    Attention scale1.5 (−1.5 to 4.4)1.1 (−2.0 to 4.3)1.1 (−3.2 to 5.4)2.3 (−2.3 to 6.9)
  • Models were adjusted for race (white, black, or other), household income (continuous, in thousands of dollars), education (graduate/professional school, bachelor's degree, some college, high school, or less than high school), marital status (married or unmarried), depressive symptoms during pregnancy (continuous), Home Observation for Measurement of the Environment scores (continuous), log10-transformed mean gestational serum cotinine concentrations, and log10-transformed mean gestational low-molecular weight urinary phthalate concentrations.

  • a Model includes child gender and a BPA level–child gender interaction term.

  • b For gender–BPA level interaction, P < .10.