TABLE 5

Clinical Care and Outcomes for Infants With Early Onset Infections (All Pathogens, GBS, and E coli)

Characteristic, n (%)aAll Patients (N = 389)Preterm (22–36 wk) With GBS or E coliTerm (37+ wk) With GBS or E coliOverall With GBS or E coli
GBS (n = 43)E coli (n = 87)GBS (n = 117)E coli (n = 20)GBS (n = 160)E coli (n = 107)P, Unadjusted (Adjusted)b
Highest care area<.001 (.2)
    Well baby nursery41 (11)0 (0)3 (3)29 (25)1 (5)29 (18)4 (4)
    Intermediate care/step down/transitional48 (12)1 (2)1 (1)24 (21)3 (15)25 (16)4 (4)
    Intensive care300 (77)42 (98)83 (95)64 (55)16 (80)106 (66)99 (93)
Infants who received intensive or intermediate careN = 348N = 43N = 84N = 88N = 19N = 131N = 103
    Respiratory distress297 (85)40 (93)79 (94)74 (84)15 (79)114 (87)94 (91).4 (.2)
    Apnea131 (38)24 (56)54 (64)15 (17)3 (16)39 (30)57 (55)<.001 (.7)
    BP support
        Volume expansion138 (40)20 (47)47 (56)18 (20)10 (53)38 (29)57 (55)<.001 (.03)
        Pressor100 (29)20 (47)41 (49)12 (14)6 (32)32 (24)47 (46)<.001 (.5)
        Steroids39 (11)6 (14)23 (27)4 (5)2 (11)10 (8)25 (24)<.001 (.07)
    Neutropeniac77 (23)14 (34)32 (41)14 (17)3 (18)28 (22)35 (36).02 (.3)
    Leukemoid reactiond41 (12)7 (16)8 (10)10 (12)0 (0)17 (13)8 (8).2 (.003)
    Thrombocytopeniae77 (22)9 (21)34 (40)10 (11)7 (37)19 (15)41 (40)<.001 (.002)
All infants
Symptomaticf310 (80)14 (34)32 (41)77 (66)19 (95)117 (73)100 (93)<.001 (.2)
  • a Data for 3 infants with both GBS and E coli were included among all patients but excluded from GBS and E coli columns. Highest care area and symptomatic percents are among all infants. Respiratory distress, apnea, blood pressure support, neutropenia, and thrombocytopenia were reported only for the 348 infants (234 with GBS or E coli) who received intensive and intermediate care.

  • b P value for a difference between infants with GBS versus E coli according to Fisher's exact or the χ2 test (unadjusted) and adjusting for GA (continuous) in a logistic regression model.

  • c Defined as absolute neutrophil count < 1000/μL on the basis of the lowest count in the first 72 hours of life. Information was missing for 19 infants overall (6 with GBS; 7 with E coli) who received intensive or intermediate care.

  • d Defined as white blood cell count > 30 000/μL based on the highest count in the first 72 hours of life. Information was missing for 2 infants overall (2 with GBS; 0 with E coli) who received intensive or intermediate care.

  • e Defined as platelet count < 100 000/μL based on the lowest count in the first 72 hours of life. Information was missing for 3 infants overall (2 with GBS; 0 with E coli) who received intensive or intermediate care.

  • f Infants were defined as symptomatic if they required blood pressure support in the first 72 hours of life or had respiratory distress, apnea, neutropenia, or thrombocytopenia.