TABLE 3

Growth in Infancy

Formula FedPBreastfed (N = 101)Comparison of 3 Dietary Groups, Pa
Control (N = 100)Nucleotide Supplemented (N = 100)
Completed study, % (n)85 (85)88 (88).496 (96).07
Age at final visit, wk20.5 ± 1.320.4 ± 1.4.620.3 ± 1.4.8
Age solids introduced, wk14.0 ± 2.313.6 ± 2.3.315.4 ± 1.8<.001b,c
Volume of formula intake, mL/d
    Age 8 wk783 ± 195827 ± 174.1
    Age 12 wk847 ± 198849 ± 199.9
    Age 20 wk739 ± 180753 ± 187.6
Anthropometric variables
Age 8 wk
    Weight, kg5.0 ± 0.65.3 ± 0.8.045.1 ± 0.7.1
    Weight, z score−0.1 ± 1.00.2 ± 1.2.040.04 ± 1.0.1
    Length, cm56.5 ± 2.456.8 ± 2.7.357.1 ± 2.3.3
    Length, z score−0.3 ± 1.0−0.1 ± 1.2.30.09 ± 0.9.1
    OFC, cm38.8 ± 1.239.3 ± 1.4.00939.1 ± 1.3.04d
    OFC, z score−0.06 ± 0.90.4 ± 1.0.0060.3 ± 0.9.02e
    BMI, kg/m215.8 ± 1.416.3 ± 1.9.0615.7 ± 1.6.05
Age 16 wk
    Weight, kg6.5 ± 0.86.8 ± 0.9.16.4 ± 0.9.03f
    Weight z score−0.05 ± 1.00.3 ± 1.2.06−0.2 ± 1.1.03g
    Length, cm61.7 ± 2.461.9 ± 2.6.662.0 ± 2.3.9
    Length, z score−0.3 ± 1.0−0.2 ± 1.1.5−0.08 ± 0.9.6
    OFC, cm41.3 ± 1.341.7 ± 1.5.0441.4 ± 1.3.1
    OFC, z score−0.3 ± 1.0−0.04 ± 1.1.01−0.1 ± 0.9.07
    BMI, kg/m217.2 ± 1.617.6 ± 1.7.0616.6 ± 1.6.001h
Age 20 wk
    Weight, kg7.3 ± 0.97.5 ± 1.0.27.1 ± 0.9.07
    Weight, z score−0.01 ± 1.10.2 ± 1.2.2−0.1 ± 1.1.1
    Length, cm64.4 ± 2.564.6 ± 2.5.764.5 ± 2.2.9
    Length, z score−0.1 ± 1.0−0.04 ± 1.0.6−0.02 ± 0.9.9
    OFC, cm42.4 ± 1.443.0 ± 1.5.0342.5 ± 1.4.07
    OFC, z score−0.3 ± 1.00.06 ± 1.1.01−0.2 ± 1.1.07
    BMI, kg/m217.4 ± 1.717.9 ± 1.7.117.2 ± 1.7.02i
Change in z score between randomization and 8 wk
    Weight0.5 ± 0.70.7 ± 0.7.02
    Length0.02 ± 1.0−0.003 ± 1.2.9
    OFC0.2 ± 0.50.4 ± 0.6.01
Change in z score between 8 and 16 wk
    Weight0.04 ± 0.50.03 ± 0.5.9−0.2 ± 0.5<.001j,k
    Length−0.04 ± 0.7−0.08 ± 0.8.7−0.2 ± 0.6.5
    OFC−0.2 ± 1.0−0.5 ± 1.0.05−0.4 ± 1.0.1
Change in z score between 16 and 20 wk
    Weight0.04 ± 0.3−0.03 ± 0.3.10.05 ± 0.3.2
    Length0.2 ± 0.70.1 ± 0.6.90.05 ± 0.5.5
    OFC−0.08 ± 1.20.2 ± 1.1.1−0.1 ± 1.2.1
  • Values are mean ± SD analyzed by using the Student's t test and percent (n) analyzed by using the χ2 test. — indicates data not applicable.

  • a The 3 dietary groups were compared by using analysis of variance and Bonferroni corrections for continuous data and χ2 test for categorical data.

  • Post-hoc analyses: breastfed versus control formula: bP < .001; jP = .001; breastfed versus nucleotide-supplemented formula: cP < .001; fP = .03; gP = .03; hP = .001; iP = .02; kP = .001; control formula versus nucleotide-supplemented formula: dP = .04; eP = .03.