TABLE 4

Microneutralization Responses According to Age Group for MF59-Adjuvanted H5N1 Influenza Vaccine

Toddlers (N = 137)Children (N = 91)Adolescents (N = 90)
Day 1 (before first dose)
    GMT (95% CI)10 (9.91–11)11 (9.89–11)11 (10–11)
    Microneutralization titer of ≥40 (95% CI), %1 (0.018–4)2 (0–8)2 (0–8)
    Microneutralization titer of ≥80 (95% CI), %1 (0.018–4)2 (0–8)1 (0–8)
Day 22 (before second dose)
    GMT (95% CI)19 (16–22)a24 (20–29)b34 (28–42)
    GMR (day 22/day 1)1.85 (1.61–2.13)a2.26 (1.87–2.74)b3.18 (2.55–3.96)
    Microneutralization titer of ≥40 (95% CI), %28 (21–37)a37 (27–47)b51 (40–62)
    Microneutralization titer of ≥80 (95% CI), %12 (7–18)18 (11–27)26 (18–35)
    Fourfold increase vs day 1 (95% CI), %27 (20–36)a34 (25–45)49 (38–60)
Day 43 (3 wk after second dose)
    GMT (95% CI)519 (454–594)c456 (377–551)313 (267–367)
    Microneutralization titer of ≥40 (95% CI), %99 (96–100)c99 (94–100)99 (94–100)
    Microneutralization titer of ≥80 (95% CI), %99 (96–100)98 (92–99)98 (92–99)
    Fourfold increase vs day 1 (95% CI), %94 (88–97)d92 (85–97)72 (62–81)
    GMR (day 43/day 1)50 (44–58)c43 (35–52)29 (25–35)
  • GMT indicates geometric mean titer; GMR, geometric mean ratio.

  • a N = 135.

  • b N = 90.

  • c N = 134.

  • d N = 132.