TABLE 3

SRH Responses According to Age Group for MF59-Adjuvanted H5N1 Influenza Vaccine

Toddlers (N = 137)Children (N = 91)Adolescents (N = 90)
Day 1 (before first dose)
    GMA (95% CI)5.00 (4.56–5.48)4.96 (4.53–5.42)4.83 (4.33–5.39)
    Seroprotection (95% CI), %3 (1–7)0 (0–4)4 (1–11)
Day 22 (before second dose)
    GMA (95% CI)13 (11–16)a17 (14–20)b19 (16–23)
    GMR (day 22/day 1)2.67 (2.24–3.18)a3.34 (2.74–4.06)b3.87 (3.25–4.61)
    Seroprotection (95% CI), %47 (38–55)a54 (44–65)b59 (48–69)
    Seroconversion (95% CI), %44 (36–53)56 (45–66)b57 (46–67)
Day 43 (3 wk after second dose)
    GMA (95% CI)78 (71–86)c74 (68–80)69 (61–77)
    Seroprotection (95% CI), %100 (97–100)c100 (96–100)100 (96–100)
    Seroconversion (95% CI), %98 (95–100)c100 (96–100)99 (94–100)
    GMR (day 43/day 1)16 (14–18)c15 (13–17)14 (12–16)
  • GMA indicates geometric mean area; GMR, geometric mean ratio.

  • a N = 135.

  • b N = 90.

  • c N = 133.