TABLE 2

HI Responses According to Age Group for MF59-Adjuvanted H5N1 Influenza Vaccine

Toddlers (N = 134)Children (N = 91)Adolescents (N = 89)
Day 1 (before first dose)
    GMT (95% CI)5.12 (4.92–5.32)5.00 (5.00–5.00)5.15 (4.90–5.43)
    Seroprotection (95% CI), %1 (0.019–4)0 (0–4)1 (0.028–6)
Day 22 (before second dose)
    GMT (95% CI)14 (11–17)a18 (13–23)b27 (20–37)
    GMR (day 22/day 1)2.67 (2.19–3.27)a3.53 (2.68–4.66)b5.23 (3.81–7.17)
    Seroprotection (95% CI), %33 (25–42)a39 (29–50)b48 (38–59)
    Seroconversion (95% CI), %33 (25–42)39 (29–50)b47 (37–58)
Day 43 (3 wk after second dose)
    GMT (95% CI)658 (560–773)a585 (484–708)b344 (261–453)
    Seroprotection (95% CI), %97 (92–99)97 (91–99)89 (80–94)
    Seroconversion (95% CI), %97 (92–99)97 (91–99)89 (80–94)
    GMR (day 43/day 1)129 (109–151)117 (97–142)67 (51–88)
  • GMT indicates geometric mean titer; GMR, geometric mean ratio.

  • a N = 131.

  • b N = 90.