TABLE 3

Patient Preoperative Characteristics for Selected Procedures

ProcedureWith Down SyndromeWithout Down SyndromeP
ASD closure
    Male, n (%)76 (43)1180 (43).9
    Age at surgery, median (IQR), mo14.4 (6.6–36.0)49.2 (26.4–91.2)<.0001
    Length, median (IQR), cm73 (63–86)102 (87–125)<.0001
    Weight, median (IQR), kg8.5 (6.0–12.2)16.0 (11.8–24.9)<.0001
    Weight z score, median (IQR)−1.9 (−2.7 to −1.1)−0.4 (−1.3 to 0.5)<.0001
    Preoperative risk factor, n (%)38 (21)199 (7)<.0001
VSD closure
    Male, n (%)392 (47)1730 (51).07
    Age at surgery, median (IQR), mo4.8 (3.2–7.1)7.4 (3.8–25.2)<.0001
    Length, median (IQR), cm60 (56–65)67 (59–87)<.0001
    Weight, median (IQR), kg5.1 (4.2–6.1)6.6 (4.8–11.6)<.0001
    Weight z score, median (IQR)−2.4 (−3.2 to −1.6)−1.6 (−2.5 to −0.5)<.0001
    Preoperative risk factor, n (%)179 (22)419 (12)<.0001
Complete AVSD repair
    Male, n (%)621 (43)158 (44).9
    Age at surgery, median (IQR), mo4.4 (3.4–5.8)4.6 (3.1–8.5).01
    Length, median (IQR), cm59 (56–62)61 (56–67)<.0001
    Weight, median (IQR), kg4.9 (4.3–5.6)5.1 (4.2–6.8).0004
    Weight z score, median (IQR)−2.4 (−3.1 to −1.7)−2.1 (−2.8 to −1.4)<.0001
    Preoperative risk factor, n (%)256 (18)61 (17).7
Mitral valve repair/replacement
    Male, n (%)141 (44)466 (48).2
    Age at surgery, median (IQR), mo32.4 (8.1–74.4)55.2 (16.8–126.0)<.0001
    Length, median (IQR), cm82 (64–104)105 (76–138)<.0001
    Weight, median (IQR), kg11.6 (6.2–17.9)16.8 (9.2–32)<.0001
    Weight z score, median (IQR)−1.9 (−2.7 to −0.7)−0.8 (−2.0 to 0.2)<.0001
    Preoperative risk factor, n (%)63 (20)195 (20)0.8
Tetralogy of Fallot repair
    Male, n (%)109 (61)1288 (59).5
    Age at surgery, median (IQR), mo5.5 (3.6–7.5)5.2 (3.2–8.2).01
    Length, median (IQR), cm62 (58–66)63 (58–69).01
    Weight, median (IQR), kg6.1 (4.9–7.1)6.4 (5.3–7.9).002
    Weight z score, median (IQR)−1.7 (−2.6 to −0.9)−0.9 (−1.9 to −0.1)<.0001
    Preoperative risk factor, n (%)27 (15)274 (12).3
  • ASD indicates atrial septal defect; VSD, ventricular septal defect; AVSD, atrioventricular septal defect.