TABLE 3

Univariable and Multivariable Regression Analysis of Factors Significantly (P < .05) Associated With ID in the CHESS Study

PredictorUnivariable OR (95% CI)P ValueAdjusted OR (95% CI)P Value
Ethnicity, white (34%) versus nonwhite (60%)2.932 (1.045–8.226).044.339 (0.774–24.330).10
Weekly or more frequent (66%) versus
 No Seizures (27%)6.135 (2.165–17.544).0010.335 (0.60–1.782).21
 Monthly/yearly seizures (24%)5.263 (1.351–20.408).021.383 (0.107–17.864).80
Age of onset >24 mo (59%) versus:
 25–60 mo (24%)9.804 (2.445–28.571).00112.987 (2.222–76.923).004
 61+ months (18%)13.889 (3.880–49.716)<.00121.277 (3.236–142.857).001
Duration, <4 y (19%) versus 8+ y (65%)7.874 (2.364–26.316).0010.564 (0.68–4.662).60
Monotherapy (28%) versus polytherapy (67%)5.286 (1.990–14.041).0027.662 (1.619–36.256).001
ASD (61%) versus non-ASD (34%)3.006 (1.028–8.795).045.863 (1.119–30.772).04
Generalized (61%) versus focal seizures (28%)4.117 (1.614–10.501).0035.579 (1.215–25.620).03
Status epilepticus (59%) versus non–status epilepticus (31%)3.193 (1.165–8.749).027.336 (1.458–36.902).02
  • Percentages indicate the proportion of children who were functioning in the ID range.