TABLE 1

Maternal Characteristics From the Full Sample of 226 932 Pregnancies Between 2012 and 2016 From OLDW

No Depression and No Antidepressant Use (n = 199 311)Depression and No Antidepressant Use (n = 4949)aAnxiety and No Antidepressant Use (n = 9406)aAntidepressant Use (n = 15 041)
Maternal age, y
 <256333 (3.2)162 (3.3)254 (2.7)404 (2.7)
 25–34135 108 (67.8)3102 (62.7)6023 (64.0)9356 (62.2)
 >3457 870 (29.0)1685 (34.0)3129 (33.3)5281 (35.1)
No. births in period
 1183 447 (92.0)4343 (87.8)8334 (88.6)13 922 (92.6)
 2+15 914 (8.0)606 (12.2)1072 (11.4)1119 (7.4)
Maternal race
 White135 734 (68.1)3741 (75.6)7161 (76.1)12 512 (83.2)
 African American14 474 (7.3)378 (7.6)598 (6.4)870 (5.8)
 Hispanic21 515 (10.8)454 (9.2)936 (10.0)1034 (6.9)
 Other or unknown27 588 (13.8)376 (7.6)711 (7.6)625 (4.2)
Education
 Less than or equal to high school or unknown21 361 (10.7)725 (14.6)1233 (13.1)2467 (16.4)
 Less than bachelor’s degree108 118 (54.2)2756 (55.7)4939 (52.5)8623 (57.3)
 Bachelor’s degree or higher59 932 (30.1)1468 (29.7)3234 (34.4)3951 (26.3)
Comorbidities and coexposuresb
 Depression diagnosis0 (0.0)4949 (100.0)1775 (18.9)5575 (37.1)
 Anxiety diagnosis0 (0.0)1775 (35.9)9406 (100.0)6293 (41.8)
 Other mental health diagnosis3584 (1.8)1334 (27.0)1909 (20.3)3206 (21.3)
 Pain diagnosis15 631 (7.8)855 (17.3)1825 (19.4)2667 (17.7)
 Sleep disorder diagnosis1109 (0.6)220 (4.5)499 (5.3)847 (5.6)
 Hypertension2120 (1.1)128 (2.6)268 (2.8)421 (2.8)
 Antipsychotics50 (0.0)50 (1.0)52 (0.6)265 (1.8)
 Benzodiazepines1522 (0.8)220 (4.4)731 (7.8)1610 (10.7)
  • All data are presented as n (%). Cell sizes <11 are suppressed per requirements of OptumLabs.

  • a A total of 1775 pregnancies included depression and anxiety diagnoses and are in both strata.

  • b Comorbidities and coexposures with claims between the LMP and 35 wk gestation.