TABLE 1

Recommended Intravenous Antibiotic Treatment Regimens for Confirmed Early- and Late-Onset GBS Bacteremia and Meningitis

GA ≤34 wkGA >34 wk
PNA ≤7 dPNA >7 dPNA ≤7 dPNA >7 d
Bacteremia
 Ampicillin50 mg/kg every 12 h75 mg/kg every 12 h50 mg/kg every 8 h50 mg/kg every 8 h
 Penicillin G50 000 U/kg every 12 h50 000 U/kg every 8 h50 000 U/kg every 12 h50 000 U/kg every 8 h
Meningitis
 Ampicillin100 mg/kg every 8 h75 mg/kg every 6 h100 mg/kg every 8 h75 mg/kg q 6 h
 Penicillin G150 000 U/kg every 8 h125 000 U/kg every 6 h150 000 U/kg every 8 h125 000 U/kg every 6 h
  • Adapted from Table 4.2. Antibacterial Drugs for Neonates (<28 Postnatal Days of Age). In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book: 2018 Report of the Committee on Infectious Diseases. 31st ed. Itasca, IL: American Academy of Pediatrics; 2018:915-919. GA, gestational age; PNA, postnatal age.