TABLE 2

Characteristics of and Standardized Differences Between Women Unexposed and Exposed to Antidepressants During Pregnancy for EDI Not Ready in 2 or More Domains

Before IPTW AppliedAfter IPTW Applied: Standardized Difference
Unexposed (n = 2197)Exposed (n = 392)Standardized Difference
n (%) or Mean (SD)n (%) or Mean (SD)
Forced variables
 Maternal characteristics
  Mother’s age at delivery27.93 (5.93)29.19 (5.59)0.217930.04185
  Rural neighborhood690 (31.41)127 (32.40)0.021270.05116
  SEFIa of neighborhood0.08 (0.92)−0.07 (0.90)0.166570.03196
 Frequency of diagnosis in the year before the conception of child
  Depressive disorder113 (5.14)64 (16.33)0.367300.03062
  Affective psychosis23 (1.05)7 (1.79)0.062560.04668
  Disorders of menstruation and other bleeding160 (7.28)18 (4.59)0.114050.07452
 Frequency of health services use in the year before conception of child
  Psychiatric care by a psychiatrist15 (0.68)6 (1.53)0.081110.00950
  Office visits: complete history and psychiatric examination in adults35 (1.59)11 (2.81)0.082780.04390
  Office visits: regional or subsequent visit or well-infant care287 (13.06)39 (9.95)0.097710.04705
  Psychotherapy by nonpsychiatrist166 (7.56)42 (10.71)0.109800.11009
 Frequency of dispensations in the year before conception of child
  SSRI: sertraline17 (0.77)18 (4.59)0.237960.01060
  SSRI: citalopram17 (0.77)22 (5.61)0.277850.04113
  SSRI: paroxetine17 (0.77)23 (5.87)0.287200.02623
  Other antidepressants: venlafaxine9 (0.41)16 (4.08)0.249760.03460
  Benzodiazepine-related drugs: lorazepam50 (2.28)15 (3.83)0.090250.07633
  Benzodiazepine-related drugs: zopiclone12 (0.55)6 (1.53)0.097220.00097
  Penicillins with extended spectrum: amoxicillin113 (5.14)13 (3.32)0.090870.07063
  Inhalants: glucocorticoids; fluticasone12 (0.55)6 (1.53)0.097220.03484
  Analgesics: opioids, natural opium alkaloids, codeine, combinations excluding psycholeptics71 (3.23)13 (3.32)0.004760.09292
  Systemic hormonal preparations (excluding sex hormones and insulins), thyroid hormones, levothyroxine sodium16 (0.73)7 (1.79)0.095020.01483
  • SEFI, Socioeconomic Factor Index.

  • a A higher SEFI score corresponds with lower neighborhood socioeconomic status.