TABLE 2

Impact of Late Effects on Parent (N = 95) and Physician (N = 41) Treatment Preferences

Late EffectParentsPhysicians
Preference WtSEOR (95% CI)PPreference WtSEOR (95% CI)P
 Cure
  80% cure−0.530.070.59 (0.51–0.67)<.001−0.560.130.57 (0.44–0.74)<.001
  90% cure0.530.071.7 (1.48–1.95)<.0010.560.131.75 (1.36–2.25)<.001
 Cardiac toxicity
  5% risk0.230.061.26 (1.11–1.42)<.0010.380.121.47 (1.16–1.86)<.001
  20% risk−0.230.060.79 (0.7–0.9)<.001−0.380.120.68 (0.54–0.86)<.001
 Infertility
  5% risk0.310.071.37 (1.19–1.57)<.0010.610.141.84 (1.39–2.43)<.001
  85% risk−0.310.070.73 (0.64–0.84)<.001−0.610.140.54 (0.41–0.72)<.001
 Second malignancy
  2% risk0.530.071.7 (1.48–1.94)<.0010.690.132 (1.56–2.56)<.001
  20% risk−0.530.070.59 (0.52–0.67)<.001−0.690.130.5 (0.39–0.64)<.001
 Neurocognitive impairment
  None1.040.122.83 (2.23–3.58)<0.0011.390.234.01 (2.58–6.24)<.001
  Mild0.750.112.11 (1.71–2.59)<.0011.230.213.43 (2.26–5.21)<.001
  Severe−1.780.140.17 (0.13–0.22)<.001−2.620.320.07 (0.04–0.14)<.001
 Abnormal growth and development
  5% risk0.220.061.24 (1.11–1.4)<.0010.300.111.35 (1.09–1.67)<.001
  20% risk−0.220.060.8 (0.71–0.9)<.001−0.300.110.74 (0.6–0.92)<.001
  • Estimated preference weights, SEs, ORs and corresponding 95% CIs, and P values for each late effect by using the conditional logit model. P values were estimated by assuming a normal distribution. CI, confidence interval.