TABLE 3

Indications for Neuroimaging Studies in Children With NF1

Indications for Consideration of Neuroimaging Studies
• Focal sensory or motor symptoms
• New onset of seizures
• Headaches that are increasing in frequency or severity
• Signs of increased intracranial pressure (headaches, visual disturbance, increased lethargy)
• Transient ischemic attack or stroke-like symptoms
• Decline in visual acuity or visual fields
• Precocious puberty or accelerated growth
• Head and neck plexiform neurofibromas increasing in size or with new development of pain
• Encephalopathy or cognitive deterioration
• Extremity asymmetry (ie, leg-length discrepancy)