Key Action Statement 3C: Clinicians should counsel that propranolol be administered with or after feeding and that doses be held at times of diminished oral intake or vomiting to reduce the risk of hypoglycemia (grade X, strong recommendation).

Aggregate Evidence QualityGrade X
BenefitsReduce the likelihood of adverse reactions
Risks, harm, costRisk that parents will decline therapy because of concerns about potential medication adverse effects
Benefit-harm assessmentBenefits outweigh harms
Intentional vaguenessNone
Role of patient preferenceNone
StrengthStrong recommendation
Key references46,60,61,76,7880