Key Action Statement 3F: Clinicians may recommend intralesional injection of triamcinolone and/or betamethasone to treat focal, bulky IHs during proliferation or in certain critical anatomic locations (eg, the lip) (grade B, moderate recommendation).

Aggregate Evidence QualityGrade B
BenefitsModest benefit in IH clearance
Risks, harm, costClinically important harms; cost of medication, visits for injection; risk of anesthesia if used
Benefit-harm assessmentBenefits outweigh harms in selected clinical situations
Intentional vaguenessNone
Role of patient preferenceShared decision-making regarding route of drug delivery
StrengthModerate recommendation
Key references3,46,103,108112