TABLE 1

SCIT Efficacy Summary

OutcomeNo. Studies, ParticipantsAllergen 
(n Studies)Comparators 
(n Studies)Summary of FindingsSOE
Asthma symptoms0Unable to draw conclusions.Insufficient
QoL2, 57Dust mite (1), Alternaria (1)SCIT versus pharmacotherapy (2)The SCIT arm improved in both trials. Control arm also improved in 1 trial. In 1 trial, researchers measured difference between arms and found no differenceLow SOE that SCIT improves asthma-related QoL
Quick-relief medication use2, 70Dust mite (2)SCIT versus placebo (1) versus control (1)1 study revealed significant reduction in No. d with salbutamol treatment in the SCIT arm when compared with control. The second study did not reveal any significant difference for either armLow SOE that SCIT reduces short-term medication use
Long-term control medication use4, 300Dust mite (3), multiple (1)SCIT versus placebo (1) versus pharmacotherapy (1) versus vitamin D + pharmacotherapy (1) versus desensitization vaccine (1)2 studies revealed significant reductions in medication use for SCIT versus comparator arm. In 1 study, researchers didn’t compare arms, and researchers in 1 study found no difference between arms. 2 studies revealed significant decrease in medicine use for SCIT arm at follow-up compared with baseline but not in the comparator armModerate SOE that SCIT reduces long-term medication use
Systemic corticosteroids2, 150Dust mite (1), multiple (1)SCIT versus placebo (1) versus control (1)The study on dust mite revealed significant decrease in No. d with systemic steroid use in the SCIT group when compared with control. The study on multiple allergens revealed no difference between groupsLow SOE that SCIT reduces systemic steroid use
Health care use2, 161Dust mite (1), multiple (1)SCIT versus placebo (1) versus pharmacotherapy (1)1 study in which researchers report increase in clinic visits but do not explain the reason or if study related. The second study revealed no differenceInsufficient
Pulmonary physiology: FEV15, 378Dust mite (3), mold (1), multiple (1)SCIT versus pharmacotherapy (3) versus vitamin D + pharmacotherapy (1) versus control (1)1 study in which researchers found significant difference in the proportion of patients with improved FEV1 in the SCIT arm when compared with pharmacotherapy. 3 studies revealed no significant difference between arms. Researchers in 1 study reported that 100% of patients in the SCIT arm had FEV1 >80% at follow-upLow SOE that SCIT improves FEV1
  • —, not applicable.