TABLE 5

Clinical, Laboratory, and Radiographic Predictors of Adverse Outcomes in Infants With Meningitis

Outcome at Last Follow-upPrognostic Marker, n (%)RR (95% CI)P
Seizures in Hospital (41)No Seizures (72)
No apparent sequelae4 (9.8)25 (35)0.28 (0.088–0.38).003
Hearing lossa4 (12)1 (1.4)8.4 (1.0–72).037
Vision problema1 (2.9)0.32
Motor problem (spasticity, paresis)a12 (35)7 (9.9)3.6 (1.5–8.3).006
Developmental delaya8 (24)4 (5.6)4.2 (1.4–13).017
Death7 (17)1 (1.4)12 (1.6–96).003
CSF protein >5 g/L (17)bCSF protein ≤5 g/L (72)b
No apparent sequelae2 (12)22 (31)0.39 (0.10–1.5).14
Hearing lossa2 (13)1 (1.5)9.2 (0.89–95).081
Vision problema01 (1.5)01.0
Motor problem (spasticity, paresis)a6 (40)9 (13)3.1 (1.3–7.3).003
Developmental delaya3 (20)3 (4.4)4.6 (1.0–21).033
Death2 (12)3 (4.1)2.8 (0.51–16).24
Hydrocephalus on neuroimaging (24)No hydrocephalus (89)
No apparent sequelae3 (13)26 (29)0.42 (0.14–1.3).12
Hearing lossa3 (14)2 (2.4)5.7 (1.0–32).028
Vision problema01 (1.2)01.0
Motor problem (spasticity, paresis)a10 (45)9 (11)4.2 (1.9–9.0)<.001
Developmental delaya3 (14)9 (11)1.3 (0.37–4.3).71
Death2 (8.3)6 (6.7)1.2 (0.27–5.7).68
  • Numbers in table represent n (%) or RR (95% CI). RR, relative risk. —, not applicable.

  • a Among survivors (n = 105).

  • b Data missing for CSF protein for 24 patients (n = 89).