TABLE 6

Multivariate Analysis of Factors Associated with Nonpublication of RCTs at 24 and 36 months After Trial Completion

Unpublished at 24 mo, OR (95% CI)PUnpublished at 36 mo, OR (95% CI)aP
Intervention
 BehavioralReferenceReference
 Drug/biologic1.36 (0.61–2.99).451.09 (0.36–3.35).88
 Device/procedure0.81 (0.29–2.28).690.72 (0.15–3.33).67
 Dietary supplement1.50 (0.57–3.94).421.66 (0.45–6.10).44
 Other1.12 (0.41–3.02).831.13 (0.30–4.35).85
Primary funding source
 AcademiaReferenceReference
 Industry2.21 (1.35–3.64).0023.12 (1.60–6.08)<.001
 Other1.37 (0.64–2.93).421.95 (0.74–5.15).18
Masking
 Open labelReferenceReference
 Single blind1.15 (0.62–2.16).650.97 (0.43–2.20).94
 Double blind1.19 (0.77–1.84).441.26 (0.75–2.14).38
Enrolled participants/ actual sample size1.00 (1.00–1.00).821.00 (1.00–1.00).31
  • a Six trials were excluded from this analysis because 36 mo had not elapsed between completion date and time that publication search was conducted.