TABLE 3

Reasons for Discontinuation of 104 RCTs

Reasonn, (%)
Patient accrual38 (36.5)
Conduct problemsa13 (12.5)
Informative terminationb13 (12.5)
Company/business decision9 (8.7)
Principle investigator left8 (7.7)
Regulatory issuec8 (7.7)
Funding issue5 (4.8)
None reported or unclear10 (9.6)
  • a Includes technical difficulties and logistical issues.

  • b Includes changes in standard of care and safety or efficacy findings.

  • c Includes issues with institutional review board or other regulatory body, including the FDA.