TABLE 4

Multivariate Analysis of Factors Associated With Discontinuation of RCTs

OR (95% CI)P
Intervention
 BehavioralReference
 Drug/biologic2.15 (0.88–5.23).09
 Device/procedure0.95 (0.28–3.24).94
 Dietary supplement1.15 (0.37–3.60).81
 Other1.54 (0.50–4.70).45
Primary funding source
 Academic institutionReference
 Industry0.46 (0.27–0.77).004
 Other0.47 (0.18–1.22).12
Masking
 Open labelReference
 Single blind0.62 (0.28–1.39).25
 Double blind0.71 (0.67–1.82).72
Planned sample size/enrollment0.999 (0.998–1.00).008