TABLE 3

Risk of Cancer in Children Conceived by ART Compared With Children Conceived Without ART, Norway, 1984–2011

Cancer SiteICCC Site GroupTotal Number of TumorsCrudeModel IIa
ARTNon-ARTTotalHR95% CIHR95% CI
LeukemiabI17101210291.520.94–2.451.67*1.02–2.73
 ALL1a97687771.030.53–1.981.160.60–2.27
 AML1b51731782.65*1.09–6.462.63*1.04–6.64
 Other leukemias1c–e371744.91*1.53–15.75.13*1.50–7.60
LymphomacII44564601.520.57–4.081.790.66–4.90
 Hodgkin'sIIa32582612.620.84–8.213.63*1.12–11.72
 Non-Hodgkin'sIIb11471480.930.13–6.690.990.14–7.28
CNScIII12100710191.250.71–2.210.920.47–1.79
 AstrocytomasIIIb53623681.710.76–3.831.450.63–3.29
 Embryonal CNS tumorsIIIc31751792.130.79–5.741.700.62–4.69
 Other gliomasIIId11041051.170.16–8.401.190.16–8.80
 Other CNS tumorsIIIf11321330.430.60–3.060.500.07–3.59
NeuroblastomaIV41841881.520.56–4.081.790.64–4.99
RetinoblastomaV190910.750.10–5.38
RenalVI32512541.370.44–4.281.400.44–4.48
HepaticVII21081102.220.54–9.071.760.41–7.46
Soft tissueIX53073121.690.70–4.091.330.54–3.30
OthersXI–XII34884911.100.35–3.441.210.38–3.82
All49441444631.270.90–1.631.210.90–1.63
  • Cancers are classified by the third version of the ICCC. The proportional hazards assumption was tested with the Schoenfeld residuals.

  • a Adjusted for birth year, birth order, maternal age at delivery, place of birth, gender, birth weight, and gestational age.

  • b In summing up the total number of cancers, each case of lymphoma and leukemia is counted only once.

  • c Analyses for sites with no cancer cases in the ART group were not performed and are therefore omitted from Table 3.

  • * Significant HRs.