TABLE 4

Bilirubin Binding Variables and Chronic Auditory Toxicity (Subgroup Analyses)

Neonates Without Auditory ToxicityNeonates With Auditory ToxicityAdjusted Odds Ratio (95% CI)P
Neonates with TSB <25 mg/dLMean (SD) (n = 58)Mean (SD) (n = 5)
 Peak TSB (mg/dLa)21.6 (1.5)22.8 (1.2)2.06 (0.92–4.6).08
 Peak BAMR0.70 (0.10)0.77 (0.18)3714 (0.44–3.10e+07).07
 Peak UB (µg/dLb)1.19 (0.70)1.99 (0.87)3.31(1.09–10.0).03
Neonates with TSB ≥25 mg/dLMean (SD) (n = 23)Mean (SD) (n = 7)
 Peak TSB (mg/dLa)28.6 (4.9)33.4 (5.4)1.18 (0.98–1.4).07
 Peak BAMR0.92 (0.20)0.99 (0.24)8.5 (0.12–596).32
 Peak UB (µg/dLb)2.07 (1.16)6.69 (4.12)7.09 (1.15–43).03
  • P values were based on logistic regression analyses predicting auditory toxicity.

  • a Indicates to multiply by 17.1 to convert to µmol/L.

  • b Indicates to multiply by 17.1 to convert to nmol/L.