TABLE 1

Intra-Alveolar Filling With Different Materials Leads to Various Disease Entities

Material Filling the Alveolar SpaceDisease
SurfactantPAP
Erythrocytes, siderophagesAlveolar hemorrhage
MacrophagesDesquamative interstitial pneumonia
Hyaline membranesDiffuse alveolar damage, RDS
EosinophilsEosinophilic pneumonia
Cholesterol crystals, foreign materialExogenous lipid pneumonia, aspiration pneumonia
Exsudative neutrophilic alveolitis, progressively replaced by macrophages, giant cells, fibroblastsMeconium aspiration syndrome
Lipoproteins, PneumocystisP jiroveci pneumonia
Calcified microlithsPulmonary alveolar microlithiasis
Plasma, serumPulmonary edema