TABLE 2

Echocardiographic Parameters and NT-proBNP During the Different Phases of 3-HB Treatment Measured in Parasternal Long Axis (M-Mode) and Two-Dimensional

DateAge, mo3-HB, mg/kg per dayIVSLVEDDPWSF,%EF, %NT-proBNP, ng/L
mmz Scoremmz Scoremmz Score
August 31, 20120.8No3−0.9218.8+0.43.4−0.1829.459.6ND
February 26, 20136.8No5.7+2.625+0.86.7+4.02856.3ND
March 10, 20137.245024+0.230.760.075 714
March 12, 20137.245031+4.15.9+2.821.945.666 762
April 10, 20138.29006+3.029+3.08.0+6.01635.032 566
May 21 20139.69007.7+4.834.4+3.47.7+5.414.632.07147
June 7, 201310.19007.5+4.533.9+3.29.1+7.515.333.318 812
June 21, 201310.614006.2+2.834.6+3.48.1+6.02348.08380
July 4, 201311.014008.7+5.631+1.67.8+4.318.539.52515
July 26, 201311.826006.8+3.328+0.47.4+3.72957.7748
August 26, 201312.826008.7+5.625.5−0.68.3+4.931.762.0417
September 27, 201313.926007.9+4.525.5−1.38.1+4.729.859.0281
October 16, 201314.526008.2+4.925.6−1.27.8+4.332.062.2372
  • Acute metabolic decompensation at the age of 7 mo occurred during 3-HB supplementation at a dose of 450 mg/kg per day. z Scores were obtained by using http://parameterz.blogspot.nl. EF, ejection fraction; IVS, interventricular septum; LVEDD, left-ventricular end-diastolic diameter; ND, not determined; No, no dose of 3-HB; PW, posterior wall; SF, shortening fraction.